发明申请
US20110243957A1 MATERIALS AND METHODS FOR PREVENTING OR TREATING NEURODEGENERATIVE CONDITIONS ASSOCIATED WITH ABETA PEPTIDE ACCUMULATION
审中-公开
用于预防或治疗与ABETA PEPTIDE累积相关的神经营养因子的材料和方法
- 专利标题： MATERIALS AND METHODS FOR PREVENTING OR TREATING NEURODEGENERATIVE CONDITIONS ASSOCIATED WITH ABETA PEPTIDE ACCUMULATION
- 专利标题（中）： 用于预防或治疗与ABETA PEPTIDE累积相关的神经营养因子的材料和方法
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申请号： US13120633申请日： 2009-09-24
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公开(公告)号： US20110243957A1公开(公告)日： 2011-10-06
- 发明人: Valentina Echeverria Moran , Gary W. Arendash
- 申请人： Valentina Echeverria Moran , Gary W. Arendash
- 申请人地址： US FL Tampa US DC Washington
- 专利权人： University of South Florida,United States Department of Veterans Affairs
- 当前专利权人： University of South Florida,United States Department of Veterans Affairs
- 当前专利权人地址： US FL Tampa US DC Washington
- 国际申请： PCT/US09/58246 WO 20090924
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K31/404 ; A61K31/44 ; A61K31/166 ; A61K31/7088 ; A61K38/17 ; A61P25/28 ; C12N5/0793
摘要：
The subject invention concerns methods for preventing and/or treating neurodegenerative conditions associated with Abeta peptide accumulation in neural tissue in a human or animal. The subject invention also concerns methods for preventing or treating Alzheimer's disease-like neuropathology in a person or animal having trisomy 21 (Down's syndrome). In one embodiment, a method of the invention comprises administering a therapeutically effective amount of a compound that inhibits function or activity of a Raf protein to a person or animal in need of treatment. In a specific embodiment, the Raf inhibitor is Sorafenib (NEXAVAR). Neurodegenerative conditions contemplated within the scope of the present invention include, for example, Alzheimer's disease and Parkinson's disease. The subject invention also concerns methods for preventing or inhibiting neuronal cell death and/or improving cell viability.
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