发明申请
- 专利标题: TETRACYCLINE INDUCIBLE TRANSCRIPTION CONTROL SEQUENCE
- 专利标题(中): 四环素诱导转录控制序列
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申请号: US13121673申请日: 2009-08-19
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公开(公告)号: US20110247088A1公开(公告)日: 2011-10-06
- 发明人: Hermann Bujard , Rainer Loew
- 申请人: Hermann Bujard , Rainer Loew
- 专利权人: TET Systems GmbH & Co., KG
- 当前专利权人: TET Systems GmbH & Co., KG
- 优先权: EP08165605.0 20081001
- 国际申请: PCT/EP2009/060728 WO 20090819
- 主分类号: A01K67/00
- IPC分类号: A01K67/00 ; C12N15/63 ; C12N5/10 ; C12N1/00 ; C07H21/04 ; A01H5/00 ; C12N15/82
摘要:
The present invention relates to inducible transcription control sequences for the regulation of gene expression. Specifically, it relates to an transcription control sequence comprising at least two tet operator sequence motifs allowing the binding of tetracycline-dependent transcriptional regulators, wherein each of the said tetracycline-dependent transcriptional regulators binds with respect to its neighbour to an opposite face of the DNA helix, and a minimal promoter comprising a TATA box which is linked at its 5′ end to a general transcription factor binding site. Further, the present invention relates to a vector, a host cell, a plant or a non-human transgenic animal comprising the said transcription control sequence. Also contemplated is a method for regulating the expression of a nucleic acid sequence being operatively linked to the transcription control sequence of the present invention in a host cell, a plant or a non-human transgenic animal.
公开/授权文献
- US09181556B2 Tetracycline inducible transcription control sequence 公开/授权日:2015-11-10