Invention Application
- Patent Title: MAGNETIC NANOPARTICLE AND METHOD FOR IMAGING T CELLS
- Patent Title (中): 磁性纳米颗粒和成像T细胞的方法
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Application No.: US12901271Application Date: 2010-10-08
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Publication No.: US20110250146A1Publication Date: 2011-10-13
- Inventor: Miqin Zhang , Jonathan Whitney Gunn , Cassian Yee
- Applicant: Miqin Zhang , Jonathan Whitney Gunn , Cassian Yee
- Applicant Address: US WA Seattle US WA Seattle
- Assignee: FRED HUTCHINSON CANCER RESEARCH CENTER,UNIVERSITY OF WASHINGTON
- Current Assignee: FRED HUTCHINSON CANCER RESEARCH CENTER,UNIVERSITY OF WASHINGTON
- Current Assignee Address: US WA Seattle US WA Seattle
- Main IPC: A61K49/14
- IPC: A61K49/14 ; C07K17/14 ; G01N24/08 ; G01N21/64 ; C07K17/00 ; A61P43/00 ; B82Y5/00
Abstract:
The present invention provides nanoparticles having a core comprising a magnetic material and having a surface, where the surface may be operatively linked to an antigenic peptide-major histocompatibility complex (MHC) monomer. The antigenic peptide-MHC monomer may then be recognized by a T cell receptor. These nanoparticles may further comprise a signal-generating label, such as a fluorophore. Methods employing nanoparticles of the present invention may involve magnetic resonance imaging and/or fluorescence detection, such that cell imaging and localization are performed.
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