发明申请
- 专利标题: SUBSTITUTED TETRAHYDROPYRAN SPIRO PYRROLIDINONE AND PIPERIDINONE, PREPARATION AND THERAPEUTIC USE THEREOF
- 专利标题(中): 取代四氢呋喃螺旋吡咯烷酮和哌啶酮,其制备和治疗用途
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申请号: US13151925申请日: 2011-06-02
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公开(公告)号: US20110251225A1公开(公告)日: 2011-10-13
- 发明人: Zhongli GAO , Ryan HARTUNG , David STEFANY
- 申请人: Zhongli GAO , Ryan HARTUNG , David STEFANY
- 申请人地址: FR Paris
- 专利权人: SANOFI
- 当前专利权人: SANOFI
- 当前专利权人地址: FR Paris
- 优先权: FR0955909 20090828
- 主分类号: A61K31/438
- IPC分类号: A61K31/438 ; A61K31/407 ; A61K31/454 ; A61K31/4545 ; A61P25/28 ; A61P25/14 ; A61P25/00 ; A61P25/24 ; A61P25/18 ; A61P25/16 ; A61P25/20 ; A61P3/04 ; C07D491/107 ; A61P25/22
摘要:
The present disclosure relates to a series of substituted N-phenyl-bipyrrolidine carboxamides of formula (I): wherein R1, R2, m, n and p are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, methods of preparation of substituted N-phenyl-bipyrrolidine carboxamides and intermediates therefore are disclosed.
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