发明申请
- 专利标题: AMIDE BASED INSULIN PRODRUGS
- 专利标题(中): 基于胰蛋白酶的PRODRUGS
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申请号: US13130966申请日: 2009-12-18
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公开(公告)号: US20110257076A1公开(公告)日: 2011-10-20
- 发明人: Richard D. DiMarchi , Binbin Kou , Shujiang Cheng
- 申请人: Richard D. DiMarchi , Binbin Kou , Shujiang Cheng
- 国际申请: PCT/US09/68716 WO 20091218
- 主分类号: A61K38/28
- IPC分类号: A61K38/28 ; A61P3/10 ; C07K14/62
摘要:
Prodrug formulations of insulin and insulin analogs are provided wherein the insulin peptide has been modified by an amide bond linkage of a dipeptide prodrug element. The prodrugs disclosed herein have extended half lives of at least 10 hours, and more typically greater than 2 hours, 20 hours and less than 70 hours, and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.
公开/授权文献
- US08697632B2 Amide based insulin prodrugs 公开/授权日:2014-04-15