发明申请
US20110257244A1 CHEMICALLY MODIFIED OLIGONUCLEOTIDES AND SMALL MOLECULES FOR USE IN REDUCING MICRO RNA ACTIVITY LEVELS AND USES THEREOF
审中-公开
化学修饰的寡核苷酸和用于减少微RNA活性水平的小分子及其用途
- 专利标题： CHEMICALLY MODIFIED OLIGONUCLEOTIDES AND SMALL MOLECULES FOR USE IN REDUCING MICRO RNA ACTIVITY LEVELS AND USES THEREOF
- 专利标题（中）： 化学修饰的寡核苷酸和用于减少微RNA活性水平的小分子及其用途
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申请号： US12863369申请日： 2009-01-16
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公开(公告)号： US20110257244A1公开(公告)日： 2011-10-20
- 发明人: Muthiah Manoharan , Kallanthottathil G. Rajeev
- 申请人： Muthiah Manoharan , Kallanthottathil G. Rajeev
- 申请人地址： US MA Cambridge
- 专利权人： ALNYLAM PHARMACEUTICALS, INC.
- 当前专利权人： ALNYLAM PHARMACEUTICALS, INC.
- 当前专利权人地址： US MA Cambridge
- 国际申请： PCT/US09/31243 WO 20090116
- 主分类号： A61K31/713
- IPC分类号： A61K31/713 ; A61P35/00 ; A61P19/06 ; A61P7/06 ; A61P25/28
摘要：
This invention relates generally to chemically modified oligonucleotides useful for modulating activity of microRNAs and pre-microRNAs. More particularly, the invention relates to single stranded chemically modified oligonucleotides for inhibiting microRNA and pre-microRNA activity and to methods of making and using the modified oligonucleotides.