发明申请
US20110263858A1 PROCESS FOR THE PREPARATION OF CLOPIDOGREL HYDROGEN SULPHATE FORM I
审中-公开
制备氯膦酸氢溴酸盐形式的方法I
- 专利标题： PROCESS FOR THE PREPARATION OF CLOPIDOGREL HYDROGEN SULPHATE FORM I
- 专利标题（中）： 制备氯膦酸氢溴酸盐形式的方法I
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申请号： US13125114申请日： 2009-10-20
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公开(公告)号： US20110263858A1公开(公告)日： 2011-10-27
- 发明人: Satish Kumar Aryan , Parendu Dhirajlal Rathod , Ram Chander Aryan , Chandra Has Khanduri
- 申请人： Satish Kumar Aryan , Parendu Dhirajlal Rathod , Ram Chander Aryan , Chandra Has Khanduri
- 优先权： IN2395/DEL/2008 20081020
- 国际申请： PCT/IB09/54626 WO 20091020
- 主分类号： C07D495/04
- IPC分类号： C07D495/04
摘要：
The present invention relates to a process for the preparation of Form 1 of (+)-(S)-∞-(2-Chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid methyl ester hydrogen sulphate commonly known as clopidogrel bisulphate. The present invention further relates to a process for reducing the residual amount of methyl isobutyl ketone and controlling the amount of mesityl oxide in clopidogrel hydrogen sulphate Form 1 by washing with ethyl acetate. Formula (I).
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