发明申请
- 专利标题: Pyridazino-pyridinone Compounds and Methods of Use
- 专利标题(中): 哒嗪 - 吡啶酮化合物和使用方法
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申请号: US13060663申请日: 2009-08-26
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公开(公告)号: US20110275629A1公开(公告)日: 2011-11-10
- 发明人: Liping H. Pettus , Andrew Tasker , Hui-Ling Wang , Bin Wu , Ryan Wurz
- 申请人: Liping H. Pettus , Andrew Tasker , Hui-Ling Wang , Bin Wu , Ryan Wurz
- 申请人地址: US CA Thousand Oaks
- 专利权人: Amgen Inc.
- 当前专利权人: Amgen Inc.
- 当前专利权人地址: US CA Thousand Oaks
- 国际申请: PCT/US09/55093 WO 20090826
- 主分类号: A61K31/5025
- IPC分类号: A61K31/5025 ; C07D413/14 ; A61K31/5377 ; A61P19/08 ; A61P19/10 ; A61P35/00 ; A61P27/02 ; A61P35/02 ; A61P5/48 ; A61P19/02 ; A61P29/00 ; A61P19/06 ; A61P11/00 ; A61P1/00 ; A61P37/08 ; A61P25/00 ; A61P17/00 ; A61P11/06 ; A61P21/00 ; A61P3/10 ; A61P37/06 ; A61P25/28 ; A61P9/10 ; A61P31/00 ; A61P31/18 ; A61P31/16 ; A61P31/14 ; A61P31/22 ; C07D471/04
摘要:
The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A, R1, R2, R3, R4, R5, R6, X and n are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of p38 map kinase mediated diseases including rheumatoid arthritis, psoriasis, chronic obstructive pulmonary disease, pain and other inflammatory disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
公开/授权文献
- US08455495B2 Pyridazino-pyridinone compounds and methods of use 公开/授权日:2013-06-04
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