A surgical stapler includes first and second tissue clamping members and a reservoir configured to hold a tissue treatment composition. The first tissue clamping member is configured to receive a plurality of staples. The second tissue clamping member comprises an anvil configured to form the staples. The reservoir may be provided in a handle portion of the surgical stapler, and a fluid conduit may be used to communicate the tissue treatment composition from the reservoir. An end effector lumen may selectively communicate with the fluid conduit. The lumen may also be in communication with openings to further communicate the tissue treatment composition to tissue or to a scaffold material positioned adjacent to tissue. A reservoir may alternatively be provided in one of the clamping members. A knife member may pierce a housing defining the reservoir, and a resilient member may then urge a tissue treatment composition from the housing.