发明申请
US20110280868A1 METHODS OF PREVENTING OR TREATING T CELL MALIGNANCIES BY ADMINISTERING ANTI-CD2 ANTAGONISTS
审中-公开
通过管理抗CD2拮抗剂预防或治疗T细胞恶性肿瘤的方法
- 专利标题： METHODS OF PREVENTING OR TREATING T CELL MALIGNANCIES BY ADMINISTERING ANTI-CD2 ANTAGONISTS
- 专利标题（中）： 通过管理抗CD2拮抗剂预防或治疗T细胞恶性肿瘤的方法
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申请号： US12466852申请日： 2009-05-15
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公开(公告)号： US20110280868A1公开(公告)日： 2011-11-17
- 发明人: Christine Dingivan , Thomas Waldmann , Zhuo Zhang , Meili Zhang
- 申请人： Christine Dingivan , Thomas Waldmann , Zhuo Zhang , Meili Zhang
- 申请人地址： US MD Rockville US MD Gaithersburg
- 专利权人： Health and Human Services, United States of America, as represented by the Sec.,Medimmune, LLC
- 当前专利权人： Health and Human Services, United States of America, as represented by the Sec.,Medimmune, LLC
- 当前专利权人地址： US MD Rockville US MD Gaithersburg
- 主分类号： A61K39/44
- IPC分类号： A61K39/44 ; A61P35/00 ; A61P35/02 ; A61K39/395
摘要：
The present invention encompasses the use of a CD2 antagonist, preferably MEDI-507, an analog, derivative or an antigen-binding fragment thereof as a single agent therapy for the prevention, treatment, management, or amelioration of cancer, particularly a T-cell malignancy, or one or more symptoms thereof. The present invention also encompasses the use of a CD2 antagonist, preferably MEDI-507, an analog, derivative or an antigen-binding fragment thereof in combination with other cancer therapies. The present invention provides pharmaceutical compositions comprising a CD2 antagonist, preferably MEDI-507, an analog, derivative or an antigen-binding fragment thereof in amounts effective to prevent, treat, manage, or ameliorate cancer, particularly a T-cell malignancy, or one or more symptoms thereof.
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