发明申请
US20110286972A1 VIRUS GROWING IN HYPOXIC CELL OR VIRUS VECTOR EXPRESSING GENE THEREIN
审中-公开
高血压病毒或病毒载体表达基因的病毒
- 专利标题： VIRUS GROWING IN HYPOXIC CELL OR VIRUS VECTOR EXPRESSING GENE THEREIN
- 专利标题（中）： 高血压病毒或病毒载体表达基因的病毒
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申请号： US12863028申请日： 2009-01-13
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公开(公告)号： US20110286972A1公开(公告)日： 2011-11-24
- 发明人: Katsuhito Takahashi , Hisako Yamamura , Masahiro Inoue
- 申请人： Katsuhito Takahashi , Hisako Yamamura , Masahiro Inoue
- 优先权： JP2008-007179 20080116
- 国际申请： PCT/JP2009/050299 WO 20090113
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C12N7/00 ; C07H21/00 ; A61P9/10 ; A61P35/00 ; A61P11/00 ; A61P9/12 ; C12N15/63 ; C07K14/005
摘要：
The present invention provides a virus or a viral vector capable of expressing a gene specifically in a cell having replication ability in a hypoxic state such as a cancer stem cell and injuring the cell, and pharmaceutical composition comprising the same. Specifically, the present invention provides a virus or a viral vector which comprises a gene encoding a fusion protein of an ODD and a protein essentially required for viral proliferation, and a pharmaceutical composition comprising the same.