发明申请
US20110294801A1 MACROCYCLICS PYRIMIDINES AS AURORA KINASE INHIBITORS
有权
MACROCYCLICS PYRIMIDINES作为AURORA激酶抑制剂
- 专利标题： MACROCYCLICS PYRIMIDINES AS AURORA KINASE INHIBITORS
- 专利标题（中）： MACROCYCLICS PYRIMIDINES作为AURORA激酶抑制剂
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申请号： US13062413申请日： 2009-09-03
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公开(公告)号： US20110294801A1公开(公告)日： 2011-12-01
- 发明人: Henry Yu , Lizbeth Celeste De Selm , Xuliang Jiang , Benny C. Askew, Jr. , Srinivasa R. Karra , Andreas Goutopoulos
- 申请人： Henry Yu , Lizbeth Celeste De Selm , Xuliang Jiang , Benny C. Askew, Jr. , Srinivasa R. Karra , Andreas Goutopoulos
- 申请人地址： DE Darmstadt
- 专利权人： MERCK PATENT GMBH
- 当前专利权人： MERCK PATENT GMBH
- 当前专利权人地址： DE Darmstadt
- 国际申请： PCT/US09/55841 WO 20090903
- 主分类号： A61K31/519
- IPC分类号： A61K31/519 ; C07D487/06 ; C07D487/16 ; A61P31/00 ; A61K31/5377 ; A61P35/00 ; A61P37/00 ; A61P29/00 ; C07D498/06 ; C07D498/16
摘要：
Macrocyclic derivative compounds that inhibit protein kinase enzymes are disclosed along with pharmaceutical compositions comprising these compounds and methods for synthesizing the same. Such compounds have utility in the treatment of proliferative diseases resulting from unregulated and/or disturbed kinase activity such as cancers, psoriasis, viral and bacterial infections, inflammatory and autoimmune diseases.
公开/授权文献
- US08815872B2 Macrocyclics pyrimidines as aurora kinase inhibitors 公开/授权日：2014-08-26
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