A front-end module (FEM) includes first and second frequency band power amplifiers (PA), first and second frequency band receiver-transmitter (RX-TX) isolation modules, and an antenna interface unit. The PAs are operable to amplify first and second frequency band outbound RF signals, respectively. The RX-TX isolation modules are operable to isolate first and second frequency band inbound RF signals from first and second frequency band outbound RF signals in accordance with first and second frequency band isolation tuning signal, respectively. The antenna interface unit is operably tuned in accordance with an antenna interface tuning signal to output at least one of the first frequency band outbound RF signal and the second frequency band outbound RF signal and to receive at least one of the first frequency band inbound RF signal and the second frequency band inbound RF signal.