发明申请
US20110305684A1 IMMUNOSTIMULATORY PROPERTIES OF OLIGONUCLEOTIDE-BASED COMPOUNDS COMPRISING MODIFIED IMMUNOSTIMULATORY DINUCLEOTIDES
审中-公开
含有寡核苷酸的化合物的免疫组织化学特性包括改性免疫球蛋白
- 专利标题： IMMUNOSTIMULATORY PROPERTIES OF OLIGONUCLEOTIDE-BASED COMPOUNDS COMPRISING MODIFIED IMMUNOSTIMULATORY DINUCLEOTIDES
- 专利标题（中）： 含有寡核苷酸的化合物的免疫组织化学特性包括改性免疫球蛋白
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申请号： US12774052申请日： 2010-05-05
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公开(公告)号： US20110305684A1公开(公告)日： 2011-12-15
- 发明人: Sudhir Agrawal , Dong Yu , Ekambar Kandimalla
- 申请人： Sudhir Agrawal , Dong Yu , Ekambar Kandimalla
- 专利权人： Idera Pharmaceuticals, Inc.
- 当前专利权人： Idera Pharmaceuticals, Inc.
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K39/39 ; A61P35/00 ; A61P37/08 ; A61P17/00 ; A61P11/00 ; A61P11/06 ; A61K39/00 ; A61P37/04
摘要：
The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides an immunostimulatory oligonucleotides for use in methods for generating an immune response or for treating a patient in need of immunostimulation. The immunostimulatory oligonucleotides of the invention preferably comprise novel purines. The immunostimulatory oligonucleotides according to the invention further comprise at least two oligonucleotides linked at their 3′ ends, internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunostimulatory oligonucleotide and having an accessible 5′ end.
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