A method, relevant equipment and system for determining a User Equipment (UE) or UEs affecting a neighboring cell are disclosed. The method for determining UE or UEs affecting a neighboring cell includes: receiving load information sent by a neighboring cell, where the load information indicates an interfered Physical Resource Block (PRB) of the neighboring cell; determining a UE or UEs that occupy, when scheduling is performed, the interfered PRB; determining UEs located in an Inter-Cell Interference Coordination (ICIC) measurement area corresponding to the neighboring cell; and obtaining an intersection of the UE or UEs that occupy, when scheduling is performed, the interfered PRB and the UE or UEs located in the ICIC measurement area corresponding to the neighboring cell. The technical solution under the present invention enables accurate determining of the UE or UEs that affect the neighboring cell.