A wireless device having a central control entity that coordinates multiple radio transceivers co-located within the same device platform to mitigate coexistence interference. The wireless device comprises an LTE transceiver, a WiFi transceiver, a BT transceiver, or a GNSS receiver. In one embodiment, the central control entity receives radio signal information from the transceivers and determines control information. The control information is used to trigger FDM solution such that the transceivers operate in designated frequency channels to mitigate co-existence interference. In another embodiment, the central control entity receives traffic and scheduling information from the transceivers and determines control information. The control information is used to trigger TDM solution such that the transceivers are scheduled for transmitting or receiving radio signals over specific time duration to mitigate co-existence interference. In yet another embodiment, power control solution is used to mitigate coexistence interference.