发明申请
US20110312989A1 INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF
失效
吲哚，1H-INDAZOLES，1,2-二苯并唑和1,2-二苯并噻唑及其制备及用途
- 专利标题： INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF
- 专利标题（中）： 吲哚，1H-INDAZOLES，1,2-二苯并唑和1,2-二苯并噻唑及其制备及用途
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申请号： US13162786申请日： 2011-06-17
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公开(公告)号： US20110312989A1公开(公告)日： 2011-12-22
- 发明人: Wenge Xie , Brian Herbert , Jianguo Ma , Truc Minh Nguyen , Richard Schumacher , Carla Maria Gauss , Ashok Tehim
- 申请人： Wenge Xie , Brian Herbert , Jianguo Ma , Truc Minh Nguyen , Richard Schumacher , Carla Maria Gauss , Ashok Tehim
- 主分类号： A61K31/416
- IPC分类号： A61K31/416 ; C07D471/08 ; C07D417/14 ; C07D413/14 ; A61K31/439 ; A61K31/428 ; A61K31/423 ; A61K31/427 ; A61K31/422 ; A61P25/18 ; A61P25/28 ; A61P25/22 ; A61P25/24 ; A61P25/00 ; A61P25/16 ; A61P25/14 ; A61P31/18 ; A61P9/00 ; A61P25/32 ; A61P25/30 ; A61P3/04 ; A61P3/10 ; A61P9/04 ; A61P23/00 ; A61P29/00 ; C07D403/14
摘要：
The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds for example, indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
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