发明申请
- 专利标题: AMIDO-TROPANE DERIVATIVES
- 专利标题(中): AMIDO-TROPANE衍生物
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申请号: US13160559申请日: 2011-06-15
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公开(公告)号: US20110312993A1公开(公告)日: 2011-12-22
- 发明人: Sabine Kolczewski , Emmanuel Pinard
- 申请人: Sabine Kolczewski , Emmanuel Pinard
- 优先权: EP10166757.4 20100622
- 主分类号: A61K31/46
- IPC分类号: A61K31/46 ; A61P25/00 ; A61P25/18 ; C07D451/02 ; A61P25/28
摘要:
The present invention relates to a compound of formula I wherein R1, R2 and R3 are each independently hydrogen, lower alkyl, lower alkoxy, cycloalkyl, lower alkyl substituted by halogen or S-lower alkyl; or to a pharmaceutically acceptable acid addition salt, racemic mixture, or corresponding enantiomer and/or optical isomer thereof. The compounds of formula I are good inhibitors of the glycine transporter 1 (GlyT-1), and have a good selectivity to glycine transporter 2 (GlyT-2) inhibitors. The compounds can be used in the treatment of neurological and neuropsychiatric disorders.
公开/授权文献
- US08153653B2 Amido-tropane derivatives 公开/授权日:2012-04-10
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