发明申请
US20110313132A1 PROCESS FOR THE PRODUCTION OF PREFORMED CONJUGATES OF ALBUMIN AND A THERAPEUTIC AGENT
审中-公开
生产ALBUMIN和治疗剂的预混合物的方法
- 专利标题： PROCESS FOR THE PRODUCTION OF PREFORMED CONJUGATES OF ALBUMIN AND A THERAPEUTIC AGENT
- 专利标题（中）： 生产ALBUMIN和治疗剂的预混合物的方法
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申请号： US13047702申请日： 2011-03-14
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公开(公告)号： US20110313132A1公开(公告)日： 2011-12-22
- 发明人: Dominique P. BRIDON , Nathalie BOUSQUET-GAGNON , Omar QURAISHI
- 申请人： Dominique P. BRIDON , Nathalie BOUSQUET-GAGNON , Omar QURAISHI
- 主分类号： C07K14/76
- IPC分类号： C07K14/76 ; C07K19/00 ; C07K1/20
摘要：
The present invention provides processes for the production of preformed albumin conjugates. In particular, the invention provides processes for the in-vitro conjugation of a therapeutic compound to recombinant albumin, wherein a therapeutic compound comprising a reactive group is contacted to recombinant albumin in solution to form a conjugate. The processes provide for conjugation to albumin species of increasing homogeneity. The resulting conjugate is purified by chromatography, in particular hydrophobic interaction chromatography comprising phenyl sepharose and butyl sepharose chromatography.
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