发明申请
- 专利标题： VARIANT DOMAIN ANTIBODIES
- 专利标题（中）： 变种域抗体
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申请号： US13058422申请日： 2009-08-13
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公开(公告)号： US20110319597A1公开(公告)日： 2011-12-29
- 发明人: Raina Jui Yu Simpson , Zehra Elgundi , Anthony Gerard Doyle , Philip Anthony Jennings , Robert Daniel Gay , Adam William Clarke
- 申请人： Raina Jui Yu Simpson , Zehra Elgundi , Anthony Gerard Doyle , Philip Anthony Jennings , Robert Daniel Gay , Adam William Clarke
- 申请人地址： AU Macquarie Park
- 专利权人： Caphalon Australia Pty. Ltd.
- 当前专利权人： Caphalon Australia Pty. Ltd.
- 当前专利权人地址： AU Macquarie Park
- 优先权： AU2008904175 20080814; AU2009902142 20090513
- 国际申请： PCT/AU2009/001043 WO 20090813
- 主分类号： C07K16/24
- IPC分类号： C07K16/24 ; C12N1/19 ; C12N1/21 ; C12N15/13 ; C12N5/10
摘要：
The present invention relates to domain antibodies which have modified framework regions such that the potency or level of binding of the domain antibody is improved. In particular the present invention relates to domain antibodies which bind TNFa in which changes have been made to framework sequences and to constructs including these domain antibodies.
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