发明申请
US20120004215A1 N-OXIDES OF DIAZABICYCLONONYL PYRIMIDINE DERIVATIVES AND THEIR MEDICAL USE
审中-公开
二氮杂环戊二烯衍生物的N-氧化物及其医疗用途
- 专利标题： N-OXIDES OF DIAZABICYCLONONYL PYRIMIDINE DERIVATIVES AND THEIR MEDICAL USE
- 专利标题（中）： 二氮杂环戊二烯衍生物的N-氧化物及其医疗用途
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申请号： US13145931申请日： 2010-01-25
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公开(公告)号： US20120004215A1公开(公告)日： 2012-01-05
- 发明人: Dan Peters , Daniel B. Timmermann , Eva Dam Christoffersen , Elsebet Østergaard Nielsen
- 申请人： Dan Peters , Daniel B. Timmermann , Eva Dam Christoffersen , Elsebet Østergaard Nielsen
- 申请人地址： DK Ballerup
- 专利权人： NEUROSEARCH A/S
- 当前专利权人： NEUROSEARCH A/S
- 当前专利权人地址： DK Ballerup
- 优先权： DKPA200900120 20090126
- 国际申请： PCT/EP2010/050759 WO 20100125
- 主分类号： A61K31/551
- IPC分类号： A61K31/551 ; A61P25/00 ; A61P25/28 ; A61P25/18 ; A61P25/24 ; A61P25/22 ; A61P3/00 ; A61P3/04 ; A61P25/20 ; A61P25/16 ; A61P25/08 ; A61P25/14 ; A61P25/04 ; A61P25/06 ; A61P29/00 ; A61P15/00 ; A61P43/00 ; A61P9/06 ; A61P21/00 ; A61P15/06 ; A61P1/12 ; A61P1/16 ; A61P17/00 ; A61P1/00 ; A61P25/30 ; A61P25/36 ; A61P25/32 ; A61P25/34 ; C07D471/08
摘要：
This invention relates to novel N-oxides of certain diazabicyclononyl pyrimidine derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.