发明申请
US20120004403A1 RNA INTERFERENCE MEDIATED INHIBITION OF TNF AND TNF RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
审中-公开
RNA干扰介导的TNF和TNF受体基因表达的抑制使用短暂的核酸（siNA）
- 专利标题： RNA INTERFERENCE MEDIATED INHIBITION OF TNF AND TNF RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
- 专利标题（中）： RNA干扰介导的TNF和TNF受体基因表达的抑制使用短暂的核酸（siNA）
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申请号： US13165635申请日： 2011-06-21
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公开(公告)号： US20120004403A1公开(公告)日： 2012-01-05
- 发明人: LEONID BEIGELMAN , JAMES MCSWIGGEN
- 申请人： LEONID BEIGELMAN , JAMES MCSWIGGEN
- 主分类号： C07H21/02
- IPC分类号： C07H21/02
摘要：
This invention relates to compounds, compositions, and methods useful for modulating tumor necrosis factor and/or tumor necrosis factor receptor gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of tumor necrosis factor and/or tumor necrosis factor receptor gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of tumor necrosis factor and/or tumor necrosis factor receptor genes, (TNF and/or TNF receptor).
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