An imaging detection system includes at least one location detection device configured to determine coordinates of a target, at least one detector configured to detect events from a source associated with the target, and a processor coupled in communication with the at least one location detection device and the at least one detector. The processor is configured to receive the coordinates from the at least one location detection device and the events from the at least one detector, translate the events using the coordinates acquired from the at least one location detection device to compensate for a relative motion between the source and the at least one detector, and output a processed data set having the events translated based on the coordinates.