发明申请
US20120009567A1 SEQUENCING REACTIONS WITH ALKALI METAL CATIONS FOR PULSE WIDTH CONTROL
有权
使用碱性金属试样进行脉冲宽度控制的序列反应
- 专利标题： SEQUENCING REACTIONS WITH ALKALI METAL CATIONS FOR PULSE WIDTH CONTROL
- 专利标题（中）： 使用碱性金属试样进行脉冲宽度控制的序列反应
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申请号： US13177775申请日： 2011-07-07
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公开(公告)号： US20120009567A1公开(公告)日： 2012-01-12
- 发明人: Andrei Fedorov , John Lyle , Keith Bjornson , Jeremiah Hanes
- 申请人： Andrei Fedorov , John Lyle , Keith Bjornson , Jeremiah Hanes
- 申请人地址： US CA Menlo Park
- 专利权人： Pacific Biosciences of California, Inc.
- 当前专利权人： Pacific Biosciences of California, Inc.
- 当前专利权人地址： US CA Menlo Park
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68
摘要：
Compositions, kits, methods and systems for single molecule nucleotide sequencing comprising producing polymerase reactions having monovalent cations that control the median pulse width for incorporated nucleotides are disclosed. The levels of alkali metals such as lithium, sodium, potassium, rubidium, and cesium in the polymerization are used to control pulse width while allowing other sequencing parameters to remain within a desirable range.
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