发明申请
US20120010186A1 HETEROCYCLIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE
审中-公开
作为硬脂酸苄酯A DELTA-9去饱和酶抑制剂的杂环化合物
- 专利标题： HETEROCYCLIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE
- 专利标题（中）： 作为硬脂酸苄酯A DELTA-9去饱和酶抑制剂的杂环化合物
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申请号： US13255922申请日： 2010-03-18
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公开(公告)号： US20120010186A1公开(公告)日： 2012-01-12
- 发明人: Nicolas Lachance , Serge Leger , Renata M. Oballa , David Powell , Geoffrey K. Tranmer , Evelyn Martins , Yves Gareau
- 申请人： Nicolas Lachance , Serge Leger , Renata M. Oballa , David Powell , Geoffrey K. Tranmer , Evelyn Martins , Yves Gareau
- 申请人地址： CA QC Kirkland
- 专利权人： MERCK FROSST CANADA LTD.
- 当前专利权人： MERCK FROSST CANADA LTD.
- 当前专利权人地址： CA QC Kirkland
- 国际申请： PCT/CA2010/000430 WO 20100318
- 主分类号： A61K31/427
- IPC分类号： A61K31/427 ; C07D487/10 ; C07D471/10 ; A61P3/06 ; A61K31/422 ; A61K31/438 ; A61K31/506 ; A61P3/10 ; C07D487/04 ; A61K31/433
摘要：
Heterocyclic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; Metabolic Syndrome; insulin resistance; cancer, liver steatosis; and non-alcoholic steatohepatitis.
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