发明申请
US20120010208A1 6-CYCLOAMINO-3-(1H-PYRROLO[2,3-b]PYRIDIN-4-YL)IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
有权
6-环丙氨基-3-(1H-吡咯并[2,3-b]吡啶-4-基)咪唑并[1,2-b]吡啶衍生物,其制备方法及其治疗用途
- 专利标题: 6-CYCLOAMINO-3-(1H-PYRROLO[2,3-b]PYRIDIN-4-YL)IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
- 专利标题(中): 6-环丙氨基-3-(1H-吡咯并[2,3-b]吡啶-4-基)咪唑并[1,2-b]吡啶衍生物,其制备方法及其治疗用途
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申请号: US13128998申请日: 2009-11-30
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公开(公告)号: US20120010208A1公开(公告)日: 2012-01-12
- 发明人: Christophe Pacaud , Frederic Puech
- 申请人: Christophe Pacaud , Frederic Puech
- 申请人地址: FR Paris
- 专利权人: SANOFI
- 当前专利权人: SANOFI
- 当前专利权人地址: FR Paris
- 优先权: FR0806723 20081201
- 国际申请: PCT/FR2009/052336 WO 20091130
- 主分类号: A61K31/5025
- IPC分类号: A61K31/5025 ; A61P25/30 ; A61P25/24 ; A61P25/22 ; C07D519/00 ; A61P25/00
摘要:
The invention relates to 6-cycloamino-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazine derivatives corresponding to the general formula (I) in which R2 represents an aryl group optionally substituted with one or more halogen atoms or C1-6-alkyl, C1-6-alkyloxy, C1-6-alkylthio, C1-6-fluoroalkyl, C1-6-fluoroalkyloxy and —CN groups or R2 represents a group chosen from C1-6-alkyl, C1-6-fluoroalkyl, C3-7-cycloalkyl or C3-7-cycloalkyl-C1-6-alkyl groups; A represents a C1-7-alkylene group; B represents a C1-7-alkylene group; L represents either a nitrogen atom optionally substituted with an Rc or Rd group, or a carbon atom substituted with an Re1 group and an Rd group or two Re2 groups; the carbon atoms of A and of B being optionally substituted with one or more Rf groups, which may be identical to or different from one another. Preparation process and therapeutic use.
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