发明申请
US20120015969A1 NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION
有权
具有选择性抑制作用的新型氨基吡啶衍生物
- 专利标题: NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION
- 专利标题(中): 具有选择性抑制作用的新型氨基吡啶衍生物
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申请号: US13259620申请日: 2010-03-15
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公开(公告)号: US20120015969A1公开(公告)日: 2012-01-19
- 发明人: Hayley Binch , Masaya Hashimoto , Michael Mortimore , Mitsuru Ohkubo , Tomoko Sunami
- 申请人: Hayley Binch , Masaya Hashimoto , Michael Mortimore , Mitsuru Ohkubo , Tomoko Sunami
- 国际申请: PCT/US2010/027279 WO 20100315
- 主分类号: A61K31/506
- IPC分类号: A61K31/506 ; C07D401/14 ; A61P35/00 ; C07D417/14
摘要:
The present invention relates to a compound of Formula (I): wherein: R1 is H, —NHCOOR1a, C5-6 cycloalkyl, or phenyl; where the cycloalkyl and phenyl each independently may be substituted with one to three of the same or different substituents selected from R10; R1a is C1-3 alkyl which may be substituted with one to three of the same or different substituents selected from F and Cl; R2 is H, —COOH, —CH2 COOH, —COOR2a, or —CH2COOR2a; R2a is C1-2 alkyl, where the alkyl may be substituted with one to three of the same or different substituents selected from halogen atoms; R3 is H, C1-6 alkyl, where the alkyl may be substituted with one to three of the same or different substituents selected from R11; R10 is F, Cl, CF3, or C1-2 alkyl; R11 is halogen atom, hydroxy, or cyano; W is selected from: W2a is H, halogen atom, cyano, C1-2 alkyl, or C3-5 cycloalkyl, or a pharmaceutically acceptable salt or ester thereof.
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