Invention Application
- Patent Title: INDOLIZINE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES
- Patent Title (中): 用于医疗用途的衍生衍生物及其用途
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Application No.: US13259621Application Date: 2010-03-30
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Publication No.: US20120015972A1Publication Date: 2012-01-19
- Inventor: Kazuo Shimizu , Masato Iizuka , Yasushi Takigawa
- Applicant: Kazuo Shimizu , Masato Iizuka , Yasushi Takigawa
- Applicant Address: JP Matsumoto-shi, Nagano
- Assignee: KISSEI PHARMACEUTICAL CO., LTD.
- Current Assignee: KISSEI PHARMACEUTICAL CO., LTD.
- Current Assignee Address: JP Matsumoto-shi, Nagano
- Priority: JP2009-086306 20090331; JP2009-279976 20091210
- International Application: PCT/JP2010/055692 WO 20100330
- Main IPC: A61K31/437
- IPC: A61K31/437 ; A61P13/12 ; A61P19/02 ; C07D471/04

Abstract:
The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level and the like. That is, the present invention relates to indolizine derivatives represented by the following formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, salts thereof or the like. In the formula, ring U represents aryl or heteroaryl; R1 represents halogen, a hydroxy group or the like; R2 represents halogen, a hydroxy group, alkyl, alkoxy, alkyl substituted by fluorine, alkoxy substituted by fluorine or the like; m represents a number from 0 to 2; n represents a number from 0 to 3; and R3 represents hydrogen, fluorine or the like.
Public/Granted literature
- US08748452B2 Indolizine derivative and use thereof for medical purposes Public/Granted day:2014-06-10
Information query
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