发明申请
- 专利标题： AMINODIHYDROTHIAZINE DERIVATIVES
- 专利标题（中）： 氨基酸衍生物
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申请号： US13243874申请日： 2011-09-23
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公开(公告)号： US20120016116A1公开(公告)日： 2012-01-19
- 发明人: Naotake KOBAYASHI , Kazuo UEDA , Naohiro ITOH , Shinji SUZUKI , Gaku SAKAGUCHI , Akira KATO , Akira YUKIMASA , Akihiro HORI , Yuji KORIYAMA , Hidekazu HARAGUCHI , Ken YASUI , Yasuhiko KANDA
- 申请人： Naotake KOBAYASHI , Kazuo UEDA , Naohiro ITOH , Shinji SUZUKI , Gaku SAKAGUCHI , Akira KATO , Akira YUKIMASA , Akihiro HORI , Yuji KORIYAMA , Hidekazu HARAGUCHI , Ken YASUI , Yasuhiko KANDA
- 申请人地址： JP Osaka
- 专利权人： SHIONOGI & CO., LTD.
- 当前专利权人： SHIONOGI & CO., LTD.
- 当前专利权人地址： JP Osaka
- 优先权： JP2005-309642 20051025; JP2006-076636 20060320
- 主分类号： C07D281/02
- IPC分类号： C07D281/02 ; C07D417/12 ; C07D417/04 ; C07D417/14 ; C07D279/08 ; C07D279/06
摘要：
A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.
公开/授权文献
- US08633188B2 Aminodihydrothiazine derivatives 公开/授权日：2014-01-21
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