发明申请
- 专利标题: NOVEL PHENYLPYRROLE DERIVATIVE
- 专利标题(中): 新颖的灵性衍生物
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申请号: US13198819申请日: 2011-08-05
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公开(公告)号: US20120022075A1公开(公告)日: 2012-01-26
- 发明人: Akihiro FURUKAWA , Takehiro FUKUZAKI , Yukari ONISHI , Hideki KOBAYASHI , Takeshi HONDA , Yumi MATSUI , Masahiro KONISHI , Kenjiro UEDA , Tetsuyoshi MATSUFUJI
- 申请人: Akihiro FURUKAWA , Takehiro FUKUZAKI , Yukari ONISHI , Hideki KOBAYASHI , Takeshi HONDA , Yumi MATSUI , Masahiro KONISHI , Kenjiro UEDA , Tetsuyoshi MATSUFUJI
- 优先权: JP2008-026519 20080206; JP2008-314479 20081210
- 主分类号: A61K31/497
- IPC分类号: A61K31/497 ; C07D401/04 ; C07D263/32 ; C07D207/323 ; A61P3/10 ; C07D409/14 ; A61K31/427 ; A61K31/4439 ; A61K31/422 ; A61K31/40 ; C07D277/28 ; C07D241/02
摘要:
The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: [wherein, A represents, for example, an oxygen atom or sulfur atom, R1 represents, for example, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 halogenated alkyl group, A and R1 together with the carbon atom bonded thereto form a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R2 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group α or a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R3 represents a hydroxy group or a C1-C6 alkoxy group, and Substituent Group α consists of, for example, a halogen atom, a C1-C6 alkyl group, a C1-C6 alkyl group substituted with 1 or 2 hydroxy group(s), a C1-C6 alkylsulfonyl group, and a group represented by the formula —V—NR5R6 (wherein, V represents a carbonyl group or a sulfonyl group, and R5 and R6 may be the same or different and respectively represent a hydrogen atom or a C1-C6 alkyl group, or R5 and R6 together with the nitrogen atom bonded thereto form a 4- to 6-membered saturated heterocycle that may be substituted with 1 or 2 group(s) independently selected from a C1-C6 alkyl group and a hydroxy group, and the 4- to 6-membered saturated heterocycle may further contain one oxygen atom or nitrogen atom)].
公开/授权文献
- US08415359B2 Phenylpyrrole derivative 公开/授权日:2013-04-09