发明申请
- 专利标题： PROCESS FOR PREPARING PYRROLIDINIUM SALTS
- 专利标题（中）： 制备吡咯烷鎓盐的方法
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申请号： US13260952申请日： 2010-04-07
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公开(公告)号： US20120022127A1公开(公告)日： 2012-01-26
- 发明人: Thomas Allmendinger
- 申请人： Thomas Allmendinger
- 国际申请： PCT/EP2010/054610 WO 20100407
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; A61P1/04 ; C07D207/12
摘要：
A two step process for preparing a compound of formula I in salt or zwitterionic form, wherein R1 and R2 are each independently C3-C8-cycloalkyl or C6-C10-aryl; and R3 and R4 are each independently C1-C8-alkyl. The process minimizes variation in the relative proportions of diastereoisomers.