- 专利标题： COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
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申请号： US13106476申请日： 2011-05-12
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公开(公告)号： US20120027874A1公开(公告)日： 2012-02-02
- 发明人: Jean-Damien Charrier , Hayley Marie Binch , Dennis James Hurley , Thomas Cleveland , Pramod Joshi , Lev Tyler Dewey Fanning , Joanne Pinder , Michael O'Donnell , Anisa Nizarali Virani , Ronald Marcellus Alphonsus Knegtel , Steven John Durrant , Stephen Clinton Young , Pierre-Henri Storck , David Kay , Philip Michael Reaper
- 申请人： Jean-Damien Charrier , Hayley Marie Binch , Dennis James Hurley , Thomas Cleveland , Pramod Joshi , Lev Tyler Dewey Fanning , Joanne Pinder , Michael O'Donnell , Anisa Nizarali Virani , Ronald Marcellus Alphonsus Knegtel , Steven John Durrant , Stephen Clinton Young , Pierre-Henri Storck , David Kay , Philip Michael Reaper
- 申请人地址： US MA Cambridge
- 专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人地址： US MA Cambridge
- 主分类号： A61K31/497
- IPC分类号： A61K31/497 ; A61K33/24 ; A61P35/00 ; C07D413/14
摘要：
The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.
公开/授权文献
- US09630956B2 Compounds useful as inhibitors of ATR kinase 公开/授权日：2017-04-25
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