发明申请
- 专利标题: SUBSTITUTED NAPHTHYRIDINES AND THEIR USE AS MEDICAMENTS
- 专利标题(中): 取代的萘啶酮及其作为药物使用
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申请号: US13013973申请日: 2011-01-26
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公开(公告)号: US20120028939A1公开(公告)日: 2012-02-02
- 发明人: Matthias Hoffmann , Georg Hoffmann , Dennis Fiegen , Sandra Handschuh , Jasna Klicic , Guenter Linz , Gerhard Schaenzle , Andreas Schnapp , Stephen Peter East , Michael Philip Mazanetz , Robert John Scott , Edward Walker
- 申请人: Matthias Hoffmann , Georg Hoffmann , Dennis Fiegen , Sandra Handschuh , Jasna Klicic , Guenter Linz , Gerhard Schaenzle , Andreas Schnapp , Stephen Peter East , Michael Philip Mazanetz , Robert John Scott , Edward Walker
- 申请人地址: DE Ingelheim am Rhein
- 专利权人: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
- 当前专利权人: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
- 当前专利权人地址: DE Ingelheim am Rhein
- 优先权: EP10152159.9 20100129
- 主分类号: A61K31/4375
- IPC分类号: A61K31/4375 ; C07D498/04 ; A61K31/496 ; A61K31/5377 ; A61K31/5383 ; A61K31/56 ; A61P11/02 ; A61P11/06 ; A61P11/00 ; A61P11/08 ; A61P29/00 ; A61P3/00 ; A61P1/00 ; A61P13/12 ; A61P1/16 ; A61P43/00 ; A61P9/00 ; A61P7/06 ; A61P27/02 ; A61P35/00 ; A61P25/00 ; A61P17/06 ; A61P19/10 ; A61P19/08 ; A61P37/06 ; C07D471/04
摘要:
The invention relates to new substituted naphthyridines of formula 1, as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, wherein R1 is selected from among —O—R3 or —NR3R4, R3 is C1-6-alkyl which is substituted by R5 and R6, R5 is selected from hydrogen, branched or linear C1-6-alkyl, C2-6-alkenyl, —C1-6-alkylen-O—C1-3-alkyl, C1-3-haloalkyl, R6 is ring X wherein n is either 0 or 1, and is a either a single or a double bond and wherein A, B, D and E are each independently from one another selected from CH2, CH, C, N, NH, O or S and wherein ring X is attached to the molecule either via position A, B, D or E, wherein said ring X may optionally be further substituted by one, two or three residues each selected individually from the group consisting of -oxo, hydroxy, —C1-3-alkyl, —C1-3-haloalkyl, —O—C1-3-alkyl, —C1-3-alkanol and halogen, and wherein R4, R2, R7, R8, R9, R10, R11 and Q may have the meanings as given in claim 1, as well as pharmaceutical compositions containing these compounds.
公开/授权文献
- US08969568B2 Substituted naphthyridines and their use as medicaments 公开/授权日:2015-03-03
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