发明申请
US20120028967A1 NOVEL DIAZA-BICYCLONONYL-PYRIMIDINYL DERIVATIVES AND THEIR MEDICAL USE
审中-公开
新型二氮杂双环嘧啶衍生物及其医药用途
- 专利标题： NOVEL DIAZA-BICYCLONONYL-PYRIMIDINYL DERIVATIVES AND THEIR MEDICAL USE
- 专利标题（中）： 新型二氮杂双环嘧啶衍生物及其医药用途
-
申请号： US13145293申请日： 2010-01-20
-
公开(公告)号： US20120028967A1公开(公告)日： 2012-02-02
- 发明人: Dan Peters , Daniel B. Timmermann , Elsebet Østergaard Nielsen , Tino Dyhring , Jeppe Kejser Christensen
- 申请人： Dan Peters , Daniel B. Timmermann , Elsebet Østergaard Nielsen , Tino Dyhring , Jeppe Kejser Christensen
- 申请人地址： DK Ballerup
- 专利权人： NEUROSEARCH A/S
- 当前专利权人： NEUROSEARCH A/S
- 当前专利权人地址： DK Ballerup
- 优先权： DKPA200900091 20090121
- 国际申请： PCT/EP2010/050609 WO 20100120
- 主分类号： A61K31/551
- IPC分类号： A61K31/551 ; A61P25/00 ; A61P25/28 ; A61P25/18 ; A61P25/24 ; A61P25/22 ; A61P25/08 ; A61P25/14 ; A61P1/00 ; A61P1/04 ; A61P11/06 ; A61P1/12 ; A61P9/12 ; A61P25/30 ; A61P25/34 ; A61P25/36 ; A61P25/32 ; C07D487/08
摘要：
This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.