- 专利标题： Short Interfering Ribonucleic Acid (siRNA) for Oral Administration
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申请号： US13218835申请日： 2011-08-26
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公开(公告)号： US20120029052A1公开(公告)日： 2012-02-02
- 发明人: François Jean-Charles NATT , Eric BILLY , Juerg HUNZIKER , Christian René SCHNELL
- 申请人： François Jean-Charles NATT , Eric BILLY , Juerg HUNZIKER , Christian René SCHNELL
- 申请人地址： CH Basel
- 专利权人： NOVARTIS AG
- 当前专利权人： NOVARTIS AG
- 当前专利权人地址： CH Basel
- 优先权： GB0608838.9 20060504
- 主分类号： A61K31/7088
- IPC分类号： A61K31/7088 ; A61P35/00 ; A61P9/00 ; A61P3/04 ; A61P9/10 ; A61P19/02 ; A61P11/06 ; A61P17/02 ; C07H21/02 ; A61P29/00
摘要：
Short interfering ribonucleic acid (siRNA) for oral administration, said siRNA comprising two separate RNA strands that are complementary to each other over at least 15 nucleotides, wherein each strand is 49 nucleotides or less, and wherein at least one of which strands contains at least one chemical modification.