Invention Application
US20120034212A1 Human Anti-IL-6 Antibodies With Extended In Vivo Half-Life And Their Use In Treatment Of Oncology, Autoimmune Diseases And Inflammatory Diseases
审中-公开
具有扩展体内半衰期的人类抗IL-6抗体及其在肿瘤学，自身免疫性疾病和炎症疾病治疗中的应用
- Patent Title: Human Anti-IL-6 Antibodies With Extended In Vivo Half-Life And Their Use In Treatment Of Oncology, Autoimmune Diseases And Inflammatory Diseases
- Patent Title (中): 具有扩展体内半衰期的人类抗IL-6抗体及其在肿瘤学，自身免疫性疾病和炎症疾病治疗中的应用
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Application No.: US13146278Application Date: 2010-01-29
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Publication No.: US20120034212A1Publication Date: 2012-02-09
- Inventor: Michael Bowen , Herren Wu , William Dall' Acqua , Peter A. Kiener , Bahija Jallal , Anthony Coyle
- Applicant: Michael Bowen , Herren Wu , William Dall' Acqua , Peter A. Kiener , Bahija Jallal , Anthony Coyle
- International Application: PCT/US10/22478 WO 20100129
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C12N15/13 ; C12N15/63 ; C12N5/10 ; C12N1/21 ; C12N1/15 ; C12N1/19 ; A61P35/00 ; A61P29/00 ; A61P19/02 ; A61P19/08 ; A61P3/00 ; A61P11/00 ; A61P11/06 ; A61P9/10 ; C07K16/24
Abstract:
The present invention provides human anti-IL-6 antibodies with extended in vivo half-life. The invention further relates to pharmaceutical compositions, therapeutic compositions, and methods using therapeutic antibodies that bind to IL-6 and that has an extended in vivo half-life for the treatment and prevention of IL-6 mediated diseases and disorders, such as, but not limited to, inflammatory diseases and disorders, autoimmune diseases and disorders and tumors.
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