发明申请
- 专利标题： LIGATION-BASED DETECTION OF GENETIC VARIANTS
- 专利标题（中）： 基于基因的遗传变异检测
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申请号： US13013732申请日： 2011-01-25
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公开(公告)号： US20120034603A1公开(公告)日： 2012-02-09
- 发明人: Arnold Oliphant , Andrew Sparks , John Stuelpnagel , Ken Song
- 申请人： Arnold Oliphant , Andrew Sparks , John Stuelpnagel , Ken Song
- 申请人地址： US CA San Jose
- 专利权人： TANDEM DIAGNOSTICS, INC.
- 当前专利权人： TANDEM DIAGNOSTICS, INC.
- 当前专利权人地址： US CA San Jose
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68
摘要：
The present invention provides assays systems and methods for detection of genetic variants in a sample, including copy number variation and single nucleotide polymorphisms. The invention preferably employs the technique of tandem ligation, i.e. the ligation of two or more fixed sequence oligonucleotides and one or more bridging oligonucleotides complementary to a region between the fixed sequence oligonucleotides.
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