发明申请
US20120035178A1 Quinuclidine Compounds as Alpha-7 Nicotinic Acetylcholine Receptor Ligands
审中-公开
奎宁环化合物作为α-7烟碱乙酰胆碱受体配体
- 专利标题： Quinuclidine Compounds as Alpha-7 Nicotinic Acetylcholine Receptor Ligands
- 专利标题（中）： 奎宁环化合物作为α-7烟碱乙酰胆碱受体配体
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申请号： US13270121申请日： 2011-10-10
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公开(公告)号： US20120035178A1公开(公告)日： 2012-02-09
- 发明人: James H. Cook, II , Ivar M. McDonald , Dalton King , Richard E. Olson , Nenghui Wang , Christiana I. Iwuagwu , F. Christopher Zusi , John E. Macor
- 申请人： James H. Cook, II , Ivar M. McDonald , Dalton King , Richard E. Olson , Nenghui Wang , Christiana I. Iwuagwu , F. Christopher Zusi , John E. Macor
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 主分类号： A61K31/53
- IPC分类号： A61K31/53 ; A61P25/28 ; A61P3/10 ; A61P29/00 ; A61P1/00 ; C07D519/00 ; A61P25/18
摘要：
The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
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