发明申请
- 专利标题： COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
- 专利标题（中）： 化合物作为ATR激酶的抑制剂有用
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申请号： US13106337申请日： 2011-05-12
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公开(公告)号： US20120035408A1公开(公告)日： 2012-02-09
- 发明人: Jean-Damien Charrier , Steven John Durrant , Stephen Clinton Young , Pierre-Henri Storck , Anisa Nizarali Virani , Phillip Michael Reaper , Joanne Pinder
- 申请人： Jean-Damien Charrier , Steven John Durrant , Stephen Clinton Young , Pierre-Henri Storck , Anisa Nizarali Virani , Phillip Michael Reaper , Joanne Pinder
- 申请人地址： US MA Cambridge
- 专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人地址： US MA Cambridge
- 主分类号： A61N5/00
- IPC分类号： A61N5/00 ; A61K31/4965 ; A61P35/00 ; A61K31/497 ; C07D401/04 ; C07D241/20 ; C07D403/04
摘要：
The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula V: wherein the variables are as defined herein.
公开/授权文献
- US09062008B2 Compounds useful as inhibitors of ATR kinase 公开/授权日：2015-06-23
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