Invention Application
- Patent Title: PROCESS FOR TUMOUR CHARACTERISTIC AND MARKER SET IDENTIFICATION, TUMOUR CLASSIFICATION AND MARKER SETS FOR CANCER
- Patent Title (中): 肿瘤特征和标记物识别,肿瘤分类和肿瘤标志物的方法
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Application No.: US13263426Application Date: 2010-04-16
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Publication No.: US20120040863A1Publication Date: 2012-02-16
- Inventor: Edwin Wang , Jie Li , Yinghai Deng , Anne E. G. Lenferink , Maureen D. O'Connor-McCourt , Enrico Purisma
- Applicant: Edwin Wang , Jie Li , Yinghai Deng , Anne E. G. Lenferink , Maureen D. O'Connor-McCourt , Enrico Purisma
- Assignee: National Research Council of Canada
- Current Assignee: National Research Council of Canada
- International Application: PCT/CA10/00565 WO 20100416
- Main IPC: C40B30/04
- IPC: C40B30/04

Abstract:
A process to identify tumour characteristics involves obtaining three different marker sets each predictive of a characteristic of interest, obtaining a sample gene expression signals from tumour cells, adding a reporter to affect a change in the sample permitting assessment of a gene expression signal of interest in the tumour, combining the gene expression signals with the reporter, correlating the extracted gene expression signals to the three different marker sets, assigning a designation to the extracted gene expression signals according to the following rankings: if the correlation of all three predictive gene expression signal sets predict it to have characteristics of concern, it is designated a bad tumour; if the correlation of all three predictive gene expression signal sets predict it to lack characteristics of concern it is designated a good tumour; and, if the correlation of all three predictive gene expression signal sets do not provide the same predicted clinical outcome, the tumour is designated as “intermediate”; and, outputting said designation.
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