Invention Application
US20120040987A1 DERIVATIVES OF 6-(6-NH-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND USE THEREOF AS MET INHIBITORS
审中-公开
6-（6-NH-取代的三唑基亚氨基 - 磺酰基）苯并噻唑和苯并咪唑的衍生物，其制备方法及其作为药物的用途，以及作为抑制剂的用途
- Patent Title: DERIVATIVES OF 6-(6-NH-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND USE THEREOF AS MET INHIBITORS
- Patent Title (中): 6-（6-NH-取代的三唑基亚氨基 - 磺酰基）苯并噻唑和苯并咪唑的衍生物，其制备方法及其作为药物的用途，以及作为抑制剂的用途
-
Application No.: US13147297Application Date: 2010-02-04
-
Publication No.: US20120040987A1Publication Date: 2012-02-16
- Inventor: Eric Bacque , Conception Nemecek , Antonio Ugolini , Sylvie Wentzler
- Applicant: Eric Bacque , Conception Nemecek , Antonio Ugolini , Sylvie Wentzler
- Applicant Address: FR Paris
- Assignee: SANOFI
- Current Assignee: SANOFI
- Current Assignee Address: FR Paris
- Priority: FR0900513 20090206
- International Application: PCT/FR2010/050179 WO 20100204
- Main IPC: A61K31/5025
- IPC: A61K31/5025 ; C07D277/82 ; A61P35/00 ; A61P21/00 ; A61P3/10 ; A61P17/06 ; A61P27/02 ; A61P19/02 ; A61P25/00 ; A61P11/06 ; A61P7/02 ; A61P3/00 ; A61P37/08 ; A61P35/04 ; C07D487/04
Abstract:
The invention relates to novel products of the formula (I) where: (II) is a single or double bond; Rb is a hydrogen or fluorine atom; Ra is a NH-Rc radical in which Rc is an optionally substituted heterocycloalkyl, aryl, heteroaryl or -alkylcycloalkyl radical; X is S, SO, or SO2; A is NH or S; W is H, alkyl, or COR with R being cycloalkyl; alkyl; alkoxy; O-phenyl; —O— (CH2)n-phenyl with n=1 to 4; or NR1R2 with R1 being H or alk and R2 is H, cycloalkyl or alkyl; or R1, R2 form a cycle together with N optionally containing O, S, N and/or NH; all of said radicals being optionally substituted; wherein said products can be in any isomer or salt form, and can be used as drugs, in particular as MET inhibitors.
Information query
IPC分类:
