发明申请
US20120041479A1 Tissue Sealant Compositions, Vascular Closure Devices, and Uses Thereof
有权
组织密封剂组合物，血管闭合装置及其用途
- 专利标题： Tissue Sealant Compositions, Vascular Closure Devices, and Uses Thereof
- 专利标题（中）： 组织密封剂组合物，血管闭合装置及其用途
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申请号： US13266161申请日： 2010-04-27
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公开(公告)号： US20120041479A1公开(公告)日： 2012-02-16
- 发明人: Bob O. Basore, JR. , William L. Neumann , Richard B. Dorshow , Raghavan Rajagopalan
- 申请人： Bob O. Basore, JR. , William L. Neumann , Richard B. Dorshow , Raghavan Rajagopalan
- 国际申请： PCT/US10/32519 WO 20100427
- 主分类号： A61B17/03
- IPC分类号： A61B17/03
摘要：
The present invention provides tissue sealant compositions and vasculature closure devices useful for the optical detection of tissue seal and/or clot formation. Compositions and devices of the present invention comprise optical dyes which undergo an observable change as the compositions and/or devices are incorporated into a tissue seal and/or clot, for example a change in fluorescence quantum yield and/or a change in visual color including a change in emission and/or absorption wavelength. Tissue sealants and vasculature closure devices of the present invention are useful for visualizing seal and/or clot formation, for example, during or after surgical procedures, after catheter removal, etc. The present invention further provides methods for formation and optical detection of tissue seals or vasculature puncture closures as well as medical kits useful for the formation and optical detection of tissue seals or vasculature puncture closures.
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