发明申请
- 专利标题: PEPTIDIC ANTIGEN THAT INDUCES ANTIBODY RECOGNIZING THREE-DIMENSIONAL STRUCTURE OF HIV AND METHOD FOR SYNTHESIZING SAME
- 专利标题(中): 诱导抗体识别HIV的三维结构的抗原抗体及其合成方法
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申请号: US13319813申请日: 2010-05-14
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公开(公告)号: US20120052090A1公开(公告)日: 2012-03-01
- 发明人: Hirokazu Tamamura , Toru Nakahara , Wataru Nomura
- 申请人: Hirokazu Tamamura , Toru Nakahara , Wataru Nomura
- 申请人地址: JP Tokyo
- 专利权人: National University Corporation Tokyo Medical and Dental University
- 当前专利权人: National University Corporation Tokyo Medical and Dental University
- 当前专利权人地址: JP Tokyo
- 优先权: JP2009-120352 20090518
- 国际申请: PCT/JP10/03280 WO 20100514
- 主分类号: A61K39/21
- IPC分类号: A61K39/21 ; C07C229/26 ; A61P37/04 ; C07C229/00 ; A61P31/18 ; C07K2/00 ; C07K1/00
摘要:
An object of the present invention is to provide an HIV antibody-inducing peptide antigen that can be used without problems for HIV, which is highly prone to mutation, and is effective in developing an antibody or a vaccine having excellent specificity and binding activity even for the three-dimensional structure of a neutralization target, i.e. the mechanism by which HIV invades a target cell; a method for synthesizing the same; a vaccine comprising the peptide antigen, or an HIV three-dimensional structure-recognizing antibody induced by the peptide antigen; and a preventive and/or therapeutic agent for HIV infection comprising the peptide antigen, the vaccine, or the HIV three-dimensional structure-recognizing antibody as an active ingredient. The synthesis method comprises using a trimer of N36 peptide derivative which is synthesized by ligating a derivative of a helical region N36 peptide in N-terminal of an HIV particle transmembrane protein gp41 to a C3-symmetric template compound having three equivalent linker structures.