发明申请
US20120053348A1 METHOD FOR PRODUCING 2-AZAADAMANTANE COMPOUND FROM BICYCLOCARBAMATE COMPOUND 有权
从双氰胺化合物生产2-氮杂异构体化合物的方法

  • 专利标题: METHOD FOR PRODUCING 2-AZAADAMANTANE COMPOUND FROM BICYCLOCARBAMATE COMPOUND
  • 专利标题(中): 从双氰胺化合物生产2-氮杂异构体化合物的方法
  • 申请号: US13265978
    申请日: 2010-04-23
  • 公开(公告)号: US20120053348A1
    公开(公告)日: 2012-03-01
  • 发明人: Masami KozawaYuki Endo
  • 申请人: Masami KozawaYuki Endo
  • 申请人地址: JP Tokyo
  • 专利权人: Nissan Chemical Industries, Ltd.
  • 当前专利权人: Nissan Chemical Industries, Ltd.
  • 当前专利权人地址: JP Tokyo
  • 优先权: JP2009-105926 20090424
  • 国际申请: PCT/JP10/57278 WO 20100423
  • 主分类号: C07D451/14
  • IPC分类号: C07D451/14
METHOD FOR PRODUCING 2-AZAADAMANTANE COMPOUND FROM BICYCLOCARBAMATE COMPOUND
摘要:
To provide a novel method for producing a 2-azaadamantane compound from a bicyclocarbamate compound.In accordance with the following scheme: a bicyclocarbamate compound represented by the formula (1) is reacted with a halogenating agent to produce a 2-azaadamantane carbamate compound represented by the formula (2), and the 2-azaadamantane carbamate compound is subjected to hydrogenolysis to produce a 2-azaadamantane compound represented by the formula (3) (in the formulae, R1 is hydrogen or the like, each of R2 and R3 which are independent of each other, is a hydrogen atom or a C1-6 alkyl group, Ar is an aryl group which may be substituted by Ra, Ra is halogen or the like, X is a halogen atom, and Y is X or a hydrogen atom).
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