A waterproof and vapor-permeable shoe, comprising a sole, provided with a vapor permeation region, an assembly insole, which is covered, toward the sole, by at least one first gasket made of waterproof material, which has at least one vapor-permeable or perforated portion above the vapor permeation region, which, once assembled, covers an upper shoe assembly, which comprises at least one vapor-permeable lining, a vapor-permeable upper, and a waterproof and vapor-permeable upper membrane that is between them, the upper shoe assembly being associated with the assembly insole, and at least one second gasket, which adheres so to form a waterproof seal to the first gasket and is glued to the lower edge of the upper, the second gasket forming a waterproof sealing region of the upper shoe assembly and the first gasket to the sole.