发明申请
- 专利标题: FLUORESCENT MRI PROBE
- 专利标题(中): 荧光MRI探针
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申请号: US13254523申请日: 2010-03-04
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公开(公告)号: US20120065384A1公开(公告)日: 2012-03-15
- 发明人: Tetsuo Nagano , Kenjiro Hanaoka , Takehiro Yamane , Yasuaki Muramatsu
- 申请人: Tetsuo Nagano , Kenjiro Hanaoka , Takehiro Yamane , Yasuaki Muramatsu
- 申请人地址: JP Tokyo
- 专利权人: THE UNIVERSITY OF TOKYO
- 当前专利权人: THE UNIVERSITY OF TOKYO
- 当前专利权人地址: JP Tokyo
- 优先权: JP2009-050203 20090304
- 国际申请: PCT/JP2010/054069 WO 20100304
- 主分类号: C07F5/00
- IPC分类号: C07F5/00
摘要:
A fluorescent gadolinium complex compound comprising a residue of gadolinium.1,4,7,10-tetraazacyclododecane-N,N′,N″,N′″-tetraacetic acid or a residue of gadolinium.diethylenetriaminepentaacetic acid bound covalently with a group represented by the following general formula (I) (R1 represents hydrogen atom or a substituent R2, R4, R5 and R7 represent hydrogen atom, a halogen atom or a C1-6 alkyl group, and R3 and R6 represent hydrogen atom, a halogen atom or a C1-6 alkyl group), which is easily taken up into cells and useful as a probe observable by the fluorescence method and MRI.
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