发明申请
- 专利标题: PROCESS FOR THE PRODUCTION OF BENZOFURANS
- 专利标题(中): 生产苯甲醚的方法
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申请号: US13321754申请日: 2010-05-26
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公开(公告)号: US20120065411A1公开(公告)日: 2012-03-15
- 发明人: Gerhard Kretzschmar , Volker Kraft , Thomas Olpp , Kai Rossen
- 申请人: Gerhard Kretzschmar , Volker Kraft , Thomas Olpp , Kai Rossen
- 申请人地址: FR Paris
- 专利权人: SANOFI
- 当前专利权人: SANOFI
- 当前专利权人地址: FR Paris
- 优先权: EP09290395.4 20090527
- 国际申请: PCT/EP2010/057270 WO 20100526
- 主分类号: C07D307/80
- IPC分类号: C07D307/80 ; C07C205/45 ; C07C201/12 ; C07C205/43
摘要:
A process for the production of 2-alkyl-3-aroyl-5-nitrobenzofurans by acylation of 2-(2-hydroxy-5-nitrophenyl)-1-aryl-ethanones and subsequent treatment of the esters with combinations of bases and proton acids or Lewis acids. This process can be used for the production of Dronedarone. Furthermore, novel intermediates for the manufacture of Dronedarone are provided.
公开/授权文献
- US08674121B2 Process for the production of benzofurans 公开/授权日:2014-03-18