发明申请
US20120071469A1 NOVEL 1,4-DIAZA-BICYCLO[3.2.1]OCTANE DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS
审中-公开
新的1,4-DIAZA-BICYCLO [3.2.1] OCTANE DERIVATIVES有用的作为NICOTINIC乙酰胆碱受体调节剂
![NOVEL 1,4-DIAZA-BICYCLO[3.2.1]OCTANE DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS](/docs/US/2012-03-22/US20120071469A1/abs.jpg.600x600.jpg)
- 专利标题： NOVEL 1,4-DIAZA-BICYCLO[3.2.1]OCTANE DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS
- 专利标题（中）： 新的1,4-DIAZA-BICYCLO [3.2.1] OCTANE DERIVATIVES有用的作为NICOTINIC乙酰胆碱受体调节剂
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申请号： US13319936申请日： 2010-05-12
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公开(公告)号： US20120071469A1公开(公告)日： 2012-03-22
- 发明人: Dan Peters , Daniel B. Timmermann , Elsebet Østergaard Nielsen , Jeppe Kejser Christensen , Tino Dyhring
- 申请人： Dan Peters , Daniel B. Timmermann , Elsebet Østergaard Nielsen , Jeppe Kejser Christensen , Tino Dyhring
- 申请人地址： DK Ballerup
- 专利权人： NEUROSEARCH A/S
- 当前专利权人： NEUROSEARCH A/S
- 当前专利权人地址： DK Ballerup
- 优先权： DKPA200900614 20090514
- 国际申请： PCT/EP10/56524 WO 20100512
- 主分类号： A61K31/551
- IPC分类号： A61K31/551 ; A61P25/00 ; A61P25/28 ; A61P25/18 ; A61P25/24 ; A61P25/22 ; A61P3/04 ; A61P25/16 ; A61P25/08 ; A61P11/06 ; A61P9/12 ; A61P29/00 ; A61P17/10 ; A61P1/00 ; A61P25/30 ; C07D487/08
![NOVEL 1,4-DIAZA-BICYCLO[3.2.1]OCTANE DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS](/abs-image/US/2012/03/22/US20120071469A1/abs.jpg.150x150.jpg)
摘要：
This invention relates to novel 1,4-diaza-bicyclo[3.2.1]octane derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.