发明申请
- 专利标题: TRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS
- 专利标题(中): 三唑化合物作为蛋白激酶抑制剂有用
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申请号: US13094183申请日: 2011-04-26
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公开(公告)号: US20120071657A1公开(公告)日: 2012-03-22
- 发明人: David Bebbington , Ronald Knegtel , Hayley Binch , Julian M.C. Golec , Pan Li , Jean-Damien Charrier
- 申请人: David Bebbington , Ronald Knegtel , Hayley Binch , Julian M.C. Golec , Pan Li , Jean-Damien Charrier
- 申请人地址: US MA Cambridge
- 专利权人: VERTEX PHARMACEUTICALS INCORPORATED
- 当前专利权人: VERTEX PHARMACEUTICALS INCORPORATED
- 当前专利权人地址: US MA Cambridge
- 主分类号: C07D403/12
- IPC分类号: C07D403/12 ; C07D401/12
摘要:
This invention describes novel triazole compounds of formula IX: wherein Z1 is nitrogen or CR9 and Z2 is nitrogen or CH, provided that at least one of Z1 and Z2 is nitrogen; G is Ring C or Ring D; Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or 1,2,4-triazinyl ring, wherein said Ring C has one or two ortho substituents independently selected from —R1; Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are independently selected from T-R3, or Rx and Ry are taken together with their intervening atoms to form a fused ring; R1, R3, and T are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of GSK-3 and Aurora, for treating diseases such as diabetes, cancer, and Alzheimer's disease.
公开/授权文献
- US08633210B2 Triazole compounds useful as protein kinase inhibitors 公开/授权日:2014-01-21
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