发明申请
- 专利标题: HOST SUPPORTED GENETIC BIOSENSORS
- 专利标题(中): 主机支持的遗传生物传感器
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申请号: US13234992申请日: 2011-09-16
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公开(公告)号: US20120076736A1公开(公告)日: 2012-03-29
- 发明人: David A. Borkholder
- 申请人: David A. Borkholder
- 申请人地址: US NY Rochester
- 专利权人: ROCHESTER INSTITUTE OF TECHNOLOGY
- 当前专利权人: ROCHESTER INSTITUTE OF TECHNOLOGY
- 当前专利权人地址: US NY Rochester
- 主分类号: A61K49/00
- IPC分类号: A61K49/00
摘要:
The present invention relates to an in vivo method of monitoring an analyte in a subject. This method involves providing an expression vector that encodes a biosensor molecule, the biosensor molecule comprising an analyte binding domain and a signal domain. The biosensor molecule produces a signal from the signal domain upon binding of the analyte by the analyte binding domain. The signal is detectable by a non-invasive means. The expression vector is introduced locally into in vivo cells of a subject under conditions effective to express the biosensor molecule in the cells. The signal from the expressed biosensor molecule is detected by a non-invasive means, thereby monitoring the analyte in the subject in vivo.